The enemies wielding this weapon can do massive damage in a matter of seconds. Also when attacked, the player will get a shaking screen with blood sprites and will be harder to aim. Enemies do not seem to reload when wielding the M60.
Due to the nature of its caliber, the M60 does more damage than the M249, but has higher recoil.
To control the weapon, fire in 2 or 3 round bursts, which is easy due to the slow rate of fire of M60.
The M60's bullets are not shared with other weapons using the same ammo.